Avian Flu Has Infected Dairy Cows in More Than a Dozen States – a Microbiologist Explains How the Virus Is Spreading

The current strain of avian flu, H5N1, is responsible for the culling of millions of domestic birds and has sickened more than a dozen farmworkers in 2024, most recently in Colorado.

The Conversation U.S. asked immunologist and microbiologist Jenna Guthmiller from the University of Colorado Anschutz Medical Campus to explain the historical roots of H5N1, its mode of transmission and how to avoid coming into contact with it.

What is H5N1?

H5N1 is a subtype of influenza A viruses. Other commonly known influenza A virus subtypes include H1N1 and H3N2, which cause seasonal outbreaks in humans.

Unlike H1N1 and H3N2, H5N1 largely infects wild birds, with waterfowl such as ducks and geese being the natural reservoirs for H5N1 viruses. Most H5N1 viruses are highly pathogenic avian influenza, meaning spillovers into other bird populations can lead to high mortality rates, including domesticated poultry.

H5N1 viruses were first identified in 1959 due to an outbreak in domesticated chickens in Scotland. In 1996, waterfowl were identified as the natural reservoir for H5N1.

Since its identification, H5N1 viruses have led to four major outbreaks: in 1997, 2003-2005, 2015 and 2021-to-present. The outbreaks in 1997 and 2003-2005 led to substantial spillover to humans.

Since 2003, nearly 900 H5N1 infections in humans have been recorded. Of those infections, more than half were fatal.