Recombinant Influenza Vaccine and Influenza Outbreaks in US Nursing Homes: Results From a Pragmatic Cluster-Randomized Clinical Trial
These findings suggest that recombinant influenza vaccines may provide clinically meaningful facility-level benefits in long-term care settings during seasons with substantial influenza circulation.
Immunogenicity and safety of an MF59-adjuvanted cell-derived higher-dose quadrivalent influenza vaccine (aQIVc) in adults aged 50 years or older: a phase 3 randomised controlled trial
In adults aged 50 years or older, aQIVc was non-inferior and superior to aQIV for all four influenza strains and non-inferiority criteria for aQIVc versus QIVr were met for A/H1N1 and both B strains, but not A/H3N2.
Effectiveness of high-dose versus standard-dose influenza vaccines against hospitalisation according to frailty risk: a prespecified analysis of the randomised trial DANFLU-2
Among adults aged 65 years or older in Denmark, frailty risk might modify the effects of HD-IIV versus SD-IIV against hospitalisation for influenza or pneumonia, with higher rVE estimates with increasing frailty risk.
Article
Scientific Papers
Viral pneumonia in older adults: from immunosenescence and chronic disease to vaccine-modifiable risk
This narrative review examines viral pneumonia in older adults at the intersection of immunosenescence, frailty, multimorbidity and immune compromise.
‘Healthy ageing’ messaging in vaccine promotion among older adults: evaluation of vaccine intention in a survey using a social marketing methodology
This study aimed to identify key elements of the social marketing 5P framework that may improve vaccination intention and ultimately vaccination uptake.
State-of-the-art of the high dose influenza vaccine in Spain
Review article - To describe the introduction, uptake, and current use of HD influenza vaccines in Spain and to summarize the evidence supporting their broader adoption in adults ≥60 years of age.
The ageing immune system and its battle with viruses
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Partner Organisations
Consensus Statement: NCDs and Immunisation – Advancing Coordinated Advocacy and Action
Provides a shared foundation for advancing adult immunisation as an important component of healthier ageing, NCD prevention, management, and care.