The impact of highly pathogenic avian influenza H5N1 virus infection on dairy cows
Highly pathogenic avian influenza (HPAI) H5N1 virus has been associated with severe mastitis in dairy cows, leading to decreased milk production.
H5N1 preparedness must integrate rural and agricultural realities
Successful implementation requires a more explicit focus: the social and infrastructural realities of rural agricultural communities where H5N1 risk is currently concentrated.
Spatiotemporal reconstruction of the North American A(H5N1) outbreak reveals successive lineage replacements by descendant reassortants
From this outbreak, we have sequenced 2955 complete A(H5N1) viral genomes from samples collected in Canada and, in conjunction with previously published data, performed multifaceted phylodynamic analyses.
Adenovirus and mRNA vaccines as well as mucosal boosting improve protective efficacy against influenza virus challenge in macaques
Current vaccines for influenza rely on inactivated or live-attenuated viruses, which can be costly and time-consuming to produce.
Susceptibility and shedding in Mx1+ and Mx1− female mice experimentally infected with dairy cattle A(H5N1) influenza viruses
Clade 2.3.4.4b highly pathogenic avian influenza A(H5N1) (HPAI H5N1) viruses have spread prolifically in dairy cattle in the US, resulting in dozens of human infections, some without well-established links to animal contacts.
Structural and functional characterization of the antigenicity of influenza A virus hemagglutinin subtype H15
Avian H15 influenza viruses are closely related to H7 viruses, but feature a unique 9-amino acid insertion in their hemagglutinin head domain, creating an additional site for antigenic variation.
Increase in H5N1 vaccine antibodies confers cross-neutralization of highly pathogenic avian influenza H5N1
The findings suggest that the current H5N1 vaccine can elicit cross-neutralization of circulating H5N1 strains, if high antibody titers are achieved.
Influenza at the human-animal interface: Summary and risk assessment, from 28 May to 1 July 2025
From 28 May to 1 July 2025, based on reporting date, the detection of influenza A (H5N1) in nine humans, influenza A (H9N2) in three humans and influenza A(H10N3) in one human were reported officially.
