Increased contact transmission of contemporary Human H5N1 compared to Bovine and Mountain Lion H5N1 in a hamster model
These findings demonstrate that the Syrian hamster model complements existing animal models for influenza A virus research and expands the resources available for investigating the pathogenicity, transmissibility, and efficacy of countermeasures.
Polymerase trapping as the mechanism of H5 highly pathogenic avian influenza virus genesis
High-pathogenicity influenza viruses have not only been devastating the planet’s wild and domestic bird populations, but they also represent a persistent threat of initiating a fatal human influenza pandemic.
Avian influenza: detections in birds decline across the EU
According to the latest quarterly monitoring report from EFSA, ECDC and the EURL, the number of recorded outbreaks is higher overall than recent years for the same period. The risk for the general public remains low.
Stabilization of the H5 clade 2.3.4.4b hemagglutinin improves vaccine-elicited neutralizing antibody responses in mice
These findings highlight that H5 HA–stabilizing mutations enhance the quality of antibody responses across different vaccine formats, underscoring their potential to improve pandemic preparedness vaccines.
FUT1- and GAL3ST2-mediated cellular glycan remodeling broadly restricts sialic acid–dependent viral infections
These findings identify FUT1 and GAL3ST2 as host restriction factors and suggest that their therapeutic dysregulation may represent a broad-spectrum antiviral strategy.
Fatal human H3N8 influenza virus has a moderate pandemic risk
This study suggests that this zoonotic H3N8 strain has moderate pandemic potential and emphasizes the continued need for avian influenza surveillance.
Potent efficacy of an NA-targeting antibody against a broad spectrum of H5N1 influenza viruses
These findings support FNI9 broad protection and underscore the NA role in future influenza vaccine design.
STING–NF-κB signaling builds an influenza spillover barrier
This suggests that STING and NF-κB form a molecular barrier that may help to prevent viruses that typically infect other species from replicating in human cells.
