Dual-route H5N1 vaccination induces systemic and mucosal immunity in murine and bovine models
Vaccine-induced immunity was consistent across species, supporting the translatability of the mouse model findings to cattle.
Highly Pathogenic Avian Influenza A(H5N1) Virus RNA in Bovine Semen, California, USA, 2024
Since March 2024, highly pathogenic avian influenza (HPAI) A(H5N1) virus has infected dairy cattle in the United States, prompting concern about novel transmission routes.
Rapid expansion of genotype D1.1 A(H5N1) influenza viruses in wild birds across North America during the 2024 migratory season
Tracking the emergence and rapid spread of D1.1 viruses in wild birds during the 2024 fall migration.
Quantifying and combating zoonotic viruses poised for emergence: Using multiplex receptor screening and decoy engineering technologies
A new and unique paradigm shift toward proactive antiviral interventions centered on host-identified multivalent “decoy” receptor therapeutics that can impose high evolutionary barriers to resistance, even in convergent evolution scenarios.
Characterisation of immune responses targeting highly pathogenic avian influenza A(H5) viruses in health-care workers in the Netherlands: an observational, cross-sectional analysis
An observational, cross-sectional study within the prospective Surveillance of Respiratory Viruses in Healthcare and Animal Workers in the Netherlands (SENTINEL) cohort.
Population immunity to clade 2.3.4.4b H5N1 is dominated by anti-neuraminidase antibodies
Findings indicate that population-level immunity to clade 2.3.4.4b H5 viruses is dominated by NA-directed antibodies, with important implications for pandemic risk assessment.
MF59-adjuvanted A/Astrakhan influenza vaccine induces cross-neutralizing H5N1 antibodies in ferrets against circulating clade 2.3.4.4b viruses
Findings suggest broad protection induced by the CSL Seqirus pandemic vaccine against contemporary clade 2.3.4.4b A(H5N1) viruses.
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Avian Influenza Weekly Update Number 1039
This weekly situation report will highlight the most recent developments in the regional response.
