TLR7 alters the maternal immune landscape during influenza A infection to increase maternal and fetal morbidity
Toll-like receptor 7 (TLR7) recognizes single-stranded RNA viruses, including IAV, yet its role in maternal immune responses and pregnancy outcomes during IAV infection is poorly understood.
Comparative Effectiveness of High-Dose and Standard-Dose Influenza Vaccines for Hospitalisation and Mortality in Adults Aged 65 and Older: An Updated Systematic Review and Meta-Analysis
High-dose inactivated influenza vaccine (HD-IV) provides superior protection compared with SD-IV against P&I and all-cause hospitalisation in older adults, with the greatest benefits among younger seniors and those without cardiovascular disease.
Adjuvanted vs High-Dose Influenza Vaccines in Older US Adults
A Cluster Randomized Crossover Study
Cross-reactive human antibody responses to H9N2 influenza virus, New York, United States, 2025
Assessed cross-reactive antibody responses to H9N2 viruses using a panel of recently collected human sera from the general population of a large metropolitan city in North America (New York City).
Immunogenicity and safety of recombinant influenza vaccine versus standard inactivated influenza vaccine in children aged 3 to 8 years: results from a phase III randomised study
Participants aged 3–8 years were randomised in a 1:1 ratio to receive the quadrivalent recombinant influenza vaccine (RIV4) or quadrivalent inactivated influenza vaccine (IIV4).
Seasonal vaccine-induced immunity shows preserved cross-reactivity to H3N2 subclade K in adults
Pre-existing immunity to subclade K variants was noted with seasonal influenza vaccination further boosting titres two-fold against subclade K and three-fold against the vaccine-like strain...
mRNA-based influenza vaccine expands the B cell response breadth in humans
Findings reveal a key role for persistent germinal center (GC) responses in broadening the repertoire of vaccine-induced antibodies.
Summary Report: IDC Stakeholder Community Meeting - 10 June 2026, Brussels
Key takeaways and next steps from the first in-person meeting of the IDC