Vaccine-Elicited Antibody Responses to Influenza A(H3N2) Subclade K
The rapid expansion of H3N2 subclade K represents a major public health concern. This study reports antibody responses to H3N2 subclade K and other influenza strains before and after influenza vaccination.
Epitope-spanning antigenic variation reprograms immunodominance and broadens immunity in sequential influenza vaccination
Immune imprinting, in which prior antigenic exposures biases recall toward dominant epitopes, constrains the breadth and durability of influenza vaccine protection.
Influenza vaccine effectiveness from nine studies during drifted A(H3N2) subclade K predominance, Europe, September 2025 to January 2026
The European 2025/26 influenza season is dominated by the influenza A(H3N2) virus, with most sequenced viruses belonging to subclade K, genetically drifted from the vaccine virus, raising concerns around vaccine effectiveness.
Adult obesity and risk of severe infections: a multicohort study with global burden estimates
Adult obesity has been linked to specific infections, but evidence across the full spectrum of infectious diseases remains scarce.
Influenza hijacks myeloid cells to inflict type-I interferon-fueled damage in the heart
Abundant evidence has correlated influenza infection with cardiovascular disease, yet mechanisms linking infection with the heart remain poorly understood.
Influenza vaccination and the risk of myocardial infarction: a meta-epidemiology study
The association between influenza vaccination and the risk of myocardial infarction (MI) remains incompletely characterized, particularly in real-world populations.
Interim 2025/26 influenza vaccine effectiveness estimates with immuno-epidemiological considerations for A(H3N2) subclade K protection, Canada, January 2026
In a pre-season influenza risk assessment publicly posted in October 2025, Canadian investigators used global genomic and antigenic surveillance data to highlight important mutations in circulating influenza A(H3N2) viruses.
Antigenic Drift and Antivaccine Shift in the 2025–2026 Influenza Season
Both viral and host factors have contributed to the intensity of influenza activity during the 2025–2026 season. Some of these factors can be managed, whereas others are largely beyond human control.