H5N1 Clade 2.3.4.4b Infections in Domestic Cats During an Avian Influenza Outbreak in Italy: Implications for One Health Surveillance
Influenza and Other Respiratory Viruses (ISRV, Wiley)
|
September 29 2026
Results:
"Pathological examination of CAT 1 revealed acute necrotizing bronchointerstitial pneumonia, non-suppurative meningoencephalitis, and disseminated foci of hepatic necrosis. Interestingly, the PB2-E627K mutation associated with mammalian virus adaptation was observed in the feline viral isolate compared to avian isolates. Such polymerase complex mutations are key determinants of host range and increase pathogenicity in mammals. CAT 2 from the same farm tested negative for AIV genome detection but subsequently seroconverted for antibodies against NPA, H5, and N1."
D’Annunzio, G., Moreno, A., Tosi, G., Bassi, P., Bortolami, A., Diegoli, G., Drago, A., Fusaro, A., Gelmini, L., Gibelli, L.R., Lazzarotto, T., Lilliu, E., Piccolomini, L.L., Maroni, A., Martini, E., Matteo, G., Mattei, G., Muscatello, L.V., Monne, I., Palumbo, E., Prezzemolo, G., Ravaioli, V., Resi, D., Ruocco, L., Sabatino, M.O., Savegnago, E., Sordilli, M., Terregino, C., Tolini, C. and Merialdi, G. (2026). H5N1 Clade 2.3.4.4b Infections in Domestic Cats During an Avian Influenza Outbreak in Italy: Implications for One Health Surveillance. Influenza and Other Respiratory Viruses, 20(9). doi:10.1111/irv.70311.
Share
Topics
Mediums
