Recombinant Influenza Vaccine and Influenza Outbreaks in US Nursing Homes: Results From a Pragmatic Cluster-Randomized Clinical Trial
Open Forum Infectious Diseases (OFID)
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October 20 2026
Conclusions:
"RIV4 reduced influenza outbreak occurrence in US nursing homes during a season with moderate influenza activity in older adults. No differences were observed during the low-circulation 2020–2021 season. These findings suggest that recombinant influenza vaccines may provide clinically meaningful facility-level benefits in long-term care settings during seasons with substantial influenza circulation."
McConeghy, K.W., Edward Davidson, H., Han, L., Canaday, D.H., Abul, Y., Hayes, K.N. and Gravenstein, S. (2026). Recombinant influenza vaccine and influenza outbreaks in US nursing homes: Results from a pragmatic cluster-randomized clinical trial. Open Forum Infectious Diseases, [online] 13(9). doi:10.1093/ofid/ofag522.
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